The Middle Magdalena Valley Basin has an area of 32 949 km2. It is located along the Central Magdalena River valley between Central and Eastern Cordilleras in the Colombian Andes. Hydrocarbon exploration has been directed mainly to the identification of structural traps in Cenozoic deposits. The stratigraphic traps have not been studied in detail. Cretaceous sequence is composed of marine to transitional calcareous and siliciclastic deposits. In contrast, Cenozoic rocks were accumulated mainly in terrestrial environments (alluvial fans and fluvial deposits with some marine influence). Three phases of deformation have been recognized: 1) extensional phase, 2) thrusting and 3) strike-slip faults.